Humira is a commonly prescribed medication used to treat various autoimmune diseases such as rheumatoid arthritis, psoriasis, Crohn’s disease, and ulcerative colitis. It belongs to a class of drugs called biologics, which are derived from living cells. Proper storage and handling of Humira are essential to maintain its effectiveness and safety. This article aims to explore the potential consequences of improper storage if Humira is not refrigerated.
How Should Humira be Stored and Handled?
Humira comes in pre-filled syringes or pens and should be stored in the refrigerator between 36°F and 46°F (2°C and 8°C). It is important to keep it away from direct light and never freeze it. Additionally, Humira can be stored at room temperature, not exceeding 77°F (25°C), for a maximum of 14 days. However, once it has been stored outside the refrigerator, it should not be returned to the fridge.
Deterioration of Effectiveness
Humira contains proteins that are susceptible to degradation when exposed to improper storage conditions. If not refrigerated within the recommended temperature range, the drug’s efficacy may decrease over time. This deterioration can result in reduced symptom relief and possibly hinder the overall treatment effectiveness. Patients may experience increased disease activity, heightened inflammation, and a decline in their quality of life if Humira’s potency diminishes due to improper storage.
Increased Risk of Infections
Improper storage of Humira can also increase the risk of infections. When biologics like Humira are stored incorrectly, the stability of the proteins within the medication may be compromised. In such cases, the body could recognize the altered proteins as foreign substances, triggering an immune response that could manifest as an infection. This increased risk of infections can pose serious health concerns, particularly for individuals with weakened immune systems.
Decreased Safety
Another potential consequence of improper storage of Humira is a decrease in safety. The drug is carefully manufactured and undergoes stringent quality control measures to ensure its safety and effectiveness. However, exposing it to temperatures outside the recommended range may compromise its stability. Reduced stability could lead to unpredictable drug behavior, such as altered drug concentrations or the presence of unwanted breakdown products. These changes may not only reduce Humira’s therapeutic effect but also introduce potential safety risks to patients.
What Should You Do If Humira Is Not Refrigerated?
If you accidentally left your Humira outside the recommended storage conditions, it is essential to consult with a healthcare professional or pharmacist. They can provide guidance on the best course of action based on the specific situation and the length of time the medication was exposed to improper storage conditions.
Short-Term Exposure
If Humira was exposed to room temperature for a short period, it may still be usable. Contact your healthcare provider or pharmacist to discuss the situation and ask for their guidance on whether it is safe to use the medication. They may recommend resuming treatment as usual or suggest a closer monitoring of your symptoms during the following weeks to ensure the medication’s continued effectiveness.
Extended Exposure
If Humira was exposed to improper storage conditions for an extended period, it is crucial not to use the medication without consulting a healthcare professional. They will assess the situation and determine the most appropriate course of action. In some cases, they may advise discarding the compromised medication and provide a replacement. It is essential to follow their instructions to ensure your safety and the effectiveness of your treatment.
Preventing Improper Storage
To prevent the potential consequences of improper storage, it is crucial to be proactive and take the necessary precautions. Here are some tips to help ensure the proper storage and handling of Humira:
Refrigeration
Store Humira in the refrigerator between 36°F and 46°F (2°C and 8°C) until you are ready to use it. If you are traveling or do not have access to a refrigerator, use an insulated bag with ice packs to keep the medication within the recommended temperature range. However, be cautious not to allow direct contact between Humira and the ice packs or expose it to freezing temperatures.
Room Temperature Storage
If you need to store Humira at room temperature due to travel or similar circumstances, make sure it does not exceed 77°F (25°C). Keep the medication away from direct light and extreme temperatures. It is also essential to note the expiration date and discard any Humira that has passed its expiration date or has been stored at room temperature for more than 14 days.
Transportation
When transporting Humira, use a cooler or insulated bag to maintain its temperature within the recommended range. This is particularly important when traveling long distances or during hot weather. Avoid leaving the medication in a car or any other location where it may be exposed to excessive heat or cold.
Communication with Pharmacist
Maintain regular communication with your pharmacist or healthcare provider regarding any concerns or questions about Humira’s storage. They can provide specific advice based on your situation and provide guidance on proper handling and storage procedures.
Conclusion
Proper storage and handling play a crucial role in maintaining the effectiveness and safety of Humira. Failure to refrigerate the medication within the recommended temperature range can lead to a deterioration of effectiveness, increased risk of infections, and decreased safety. If Humira is not refrigerated as directed, it is important to consult a healthcare professional or pharmacist for guidance. By taking proactive measures and following the recommended storage guidelines, patients can ensure the optimal use of Humira and maximize its potential benefits in managing their autoimmune conditions.